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Al-Ayoubi,, D., Seehy, M. (2003). ACRYLAMIDE INDUCED GENOTOXIC EFFECT IN GOLDEN HAMSTER (Mesocricetus auratus) GENOME. Journal of Plant Production, 28(9), 6701-6711. doi: 10.21608/jpp.2003.252718
D. Y. Al-Ayoubi,; M. A. Seehy. "ACRYLAMIDE INDUCED GENOTOXIC EFFECT IN GOLDEN HAMSTER (Mesocricetus auratus) GENOME". Journal of Plant Production, 28, 9, 2003, 6701-6711. doi: 10.21608/jpp.2003.252718
Al-Ayoubi,, D., Seehy, M. (2003). 'ACRYLAMIDE INDUCED GENOTOXIC EFFECT IN GOLDEN HAMSTER (Mesocricetus auratus) GENOME', Journal of Plant Production, 28(9), pp. 6701-6711. doi: 10.21608/jpp.2003.252718
Al-Ayoubi,, D., Seehy, M. ACRYLAMIDE INDUCED GENOTOXIC EFFECT IN GOLDEN HAMSTER (Mesocricetus auratus) GENOME. Journal of Plant Production, 2003; 28(9): 6701-6711. doi: 10.21608/jpp.2003.252718

ACRYLAMIDE INDUCED GENOTOXIC EFFECT IN GOLDEN HAMSTER (Mesocricetus auratus) GENOME

Article 11, Volume 28, Issue 9, September 2003, Page 6701-6711  XML PDF (565 K)
Document Type: Original Article
DOI: 10.21608/jpp.2003.252718
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Authors
D. Y. Al-Ayoubi,1; M. A. Seehy2
1Girl’s College of Education, Genetics , Riyadh, Saudia
2Dept. of Genetics , Fac. Of Agric. , Alexandria Univ. , Egypt
Abstract
This work aims at dislosing the capability of acrylamide in causing genotoxic effect in golden hamster genome. To achieve such a purpose, five different doses that ranged from 1 to 20 mg/ kg b. wt. were chosen and tested employing three genotoxic bioassays. These assays are : 1-Estimation of cell proliferation, 2-Analysis of chromosomal abnormalities; and 3-In vivo induction of sister chromatid exchanges.
The results obtained showed that all tested doses were found to be toxic and cellular toxicity was observed. Analysis o chromosomal aberrations revealed that acrylamide is a positive clastogenic agent. Sister chromatid exchange assay indicated that acrylamide is a powerful inducer of primary genetic damage.
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